The objective of this study was to develop simple, precise, accurate and sensitive UV spectrophotometric methods for the simultaneous determination of ofloxacin (OFX) and flavoxate HCl (FLX) in pharmaceutical formulations. In the method difference spectrophotometric at 239.6 nm for OFX (zero crossing for FLV) and at 332.4 nm for FLV (zero crossing for OFX) was used for the determination of the drugs and the linearity range was found to be 5 to 25 μg/ml for both OFX and FLV. The accuracy and precision of the methods were determined and validated statistically. This method showed good reproducibility and recovery with % RSD less than 1.5%. This method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of OFX and FLV in combined dosage form.
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